During the Obama years, the Republicans have done an unprecedented amount of stonewalling on cabinet-and-below appointees. I would also argue that their war on judicial nominees has been way beyond what went before. Really, if the president nominated God to serve on the D.C. Court of Appeals, Mitch McConnell would threaten a filibuster.
Until Eleanor Roosevelt, there was only one or two First Ladies in all of American history who made an impact, who people could even have recognized or identified. And it's really only been since Jackie Kennedy that there's been this idea that the family life of the president is such a central thing.